Anus carcinoma cell squamous

Metrics details. The incidence of anal squamous cell carcinoma SCC has been steadily growing globally in the past decade. Clinical data on anal SCC from China are rare. We conducted this study to describe the clinical and epidemiological characteristics of anal SCC in China and explore prognostic factors of outcomes among patients with anal SCC. We audited demographic characteristics, relevant symptoms, risk factors, treatment modalities and outcomes for patients diagnosed with anal SCC at 11 medical institutions in China between January and July
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06.05.2020
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Anal Cancer

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Squamous cell carcinoma of the anal canal

Anal cancers are rare tumours; however, the incidence is increasing in both men and women. Changing trends in sexual behaviour, smoking, and infection with the human papillomavirus are thought to be responsible for the increase. The standard systemic treatment of metastatic disease remains cisplatin and 5-fluorouracil, and aside from several non-randomised small phase II trials there has been no real progress over the past two decades. Based on the efficacy of cetuximab in squamous cell carcinomas from other primary sites, there appears to be clinical rationale for evaluation of anti-epidermal growth factor inhibitors in anal squamous cell carcinoma. In order to facilitate research and implement more effective treatment strategies international collaboration in clinical trials incorporating tissue collection for biomarkers is essential. However, the incidence is increasing in certain populations with high-risk behaviour and in those with the human immunodeficiency virus HIV [ 2 , 3 ]. Other risk factors include smoking, increased number of sexual partners, sexually transmitted infections, a history of vaginal or cervical malignancy, other conditions associated with lowered immunity, for example, transplant recipients and those with anal inflammatory conditions.
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What Is Anal Cancer?

The anus is connected to the rectum by the anal canal. The anal canal has two ring-shaped muscles called sphincter muscles that keep the anus closed and prevent stool from leaking out. The anal verge is where the canal connects to the outside skin at the anus. This skin around the anal verge is called the perianal skin previously called the anal margin.
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The dominant etiology is infection with human papilloma virus HPV , which is the most common sexually transmitted disease in the United States. Vaccines directed against oncogenic HPV serotypes exist, and their utility for preventing anal neoplasia is under investigation. Additional risk factors for developing SCC include HIV infection, anal receptive intercourse, smoking, and immunosuppression.
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